Research Articles
Advanced Feature Engineering for CGM Time Series Data: From Fundamentals to Clinical Translation
This article provides a comprehensive guide to feature engineering for Continuous Glucose Monitoring (CGM) time series data, tailored for researchers, scientists, and drug development professionals.
Closed-Loop Control System Design for the Artificial Pancreas: From Foundational Algorithms to Clinical Implementation
This article provides a comprehensive review of the engineering and algorithmic foundations of Artificial Pancreas (AP) systems for automated glucose management in diabetes.
Ex Vivo Jejunal Sac Assay: A Comprehensive Guide to Measuring Glucose Absorption for Drug Discovery and Research
This article provides a detailed guide on the ex vivo everted jejunal sac technique, a fundamental tool for investigating intestinal glucose absorption mechanisms.
Mastering the Caco-2/TC7 Glucose Uptake Assay: A Comprehensive Guide from Foundations to Advanced Applications
This article provides a definitive guide to conducting in vitro glucose uptake assays using the human intestinal Caco-2/TC7 cell model.
The Sorensen Model: A Comprehensive Guide to High-Fidelity Glucose-Insulin Simulation for Biomedical Research
This article provides a comprehensive exploration of the Sorensen physiological model, a foundational yet complex multi-compartmental framework for simulating glucose-insulin dynamics.
Advances in CGM Sensor Error Analysis and Calibration Algorithms: A Technical Review for Biomedical Research
This article provides a comprehensive technical review of continuous glucose monitoring (CGM) systems, focusing on the sources of sensor error and the evolution of calibration methodologies.
Model Predictive Control for Blood Glucose Regulation: Algorithm Design, Clinical Validation, and Future Directions
This comprehensive review examines Model Predictive Control (MPC) algorithms for automated blood glucose regulation in type 1 diabetes.
Glucotoxicity: Molecular Mechanisms of Hyperglycemia-Induced Metabolic Decline and Therapeutic Strategies
This article provides a comprehensive analysis of glucotoxicity, the pathophysiological process where chronic hyperglycemia induces further metabolic deterioration, creating a self-perpetuating cycle in diabetes.
The Dawn Phenomenon: Hormonal Surges, Circadian Regulation, and Therapeutic Targeting in Glucose Metabolism
This article provides a comprehensive analysis of the dawn phenomenon, a common cause of early-morning hyperglycemia affecting over 50% of individuals with diabetes.
Intestinal Glucose Transport: Unraveling the Critical Roles and Therapeutic Targeting of SGLT1 and GLUT2
This article provides a comprehensive analysis of the sodium-glucose cotransporter SGLT1 and the facilitative glucose transporter GLUT2 in intestinal glucose absorption, a process critical for systemic energy homeostasis.