Research Articles
Glucotoxicity: Molecular Mechanisms of Hyperglycemia-Induced Metabolic Decline and Therapeutic Strategies
This article provides a comprehensive analysis of glucotoxicity, the pathophysiological process where chronic hyperglycemia induces further metabolic deterioration, creating a self-perpetuating cycle in diabetes.
The Dawn Phenomenon: Hormonal Surges, Circadian Regulation, and Therapeutic Targeting in Glucose Metabolism
This article provides a comprehensive analysis of the dawn phenomenon, a common cause of early-morning hyperglycemia affecting over 50% of individuals with diabetes.
Intestinal Glucose Transport: Unraveling the Critical Roles and Therapeutic Targeting of SGLT1 and GLUT2
This article provides a comprehensive analysis of the sodium-glucose cotransporter SGLT1 and the facilitative glucose transporter GLUT2 in intestinal glucose absorption, a process critical for systemic energy homeostasis.
Dietary Proteins and Amino Acids in Glucose Homeostasis: Molecular Mechanisms, Clinical Applications, and Therapeutic Potential
This article synthesizes current evidence on the complex, dual role of dietary proteins and amino acids in regulating glucose metabolism.
From Glucose to ATP: Molecular Mechanisms, Metabolic Regulation, and Therapeutic Targeting
This article provides a comprehensive analysis of the molecular machinery and regulatory networks governing cellular glucose uptake and utilization for ATP production.
From Amino Acids to Glucose: Molecular Mechanisms, Regulatory Networks, and Therapeutic Targeting of Hepatic Gluconeogenesis
This article provides a comprehensive analysis of the gluconeogenesis pathway, with a specialized focus on the conversion of glucogenic amino acids into glucose.
Thyroid Hormones T3 and T4 as Central Regulators of Basal Metabolic Rate: Molecular Mechanisms, Metabolic Integration, and Therapeutic Potential
Thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3), are primary determinants of mammalian basal metabolic rate (BMR), regulating energy expenditure, thermogenesis, and the metabolism of carbohydrates, lipids, and proteins across...
The Inflammatory Signal: How a Single Protein May Hold the Key to Diabetic Foot Ulcers
Discover how APOE pro-inflammatory signaling contributes to diabetic foot ulcers through groundbreaking single-cell research
The Red Revolution: How Astaxanthin Tames Inflammation in Type 2 Diabetes
Discover how astaxanthin, a powerful natural antioxidant, modulates inflammation in Type 2 diabetes through regulation of microRNAs and metabolic markers.
The Tiny Messengers Offering New Hope for Type 2 Diabetes
Discover how stem cell-derived extracellular vesicles combat oxidative damage in Type 2 Diabetes through the miR-191-5p/DAPK1/AKT pathway