Research Articles
Diabetes Medications and Cancer Risk: The Unexpected Connection
Exploring the fascinating connection between diabetes medications and cancer risk, including protective effects and therapeutic potential.
The Sugar Switch: How a Tiny Molecular Modification Fuels Inflammation and Cancer
Explore the fascinating relationship between O-GlcNAcylation and NF-κB regulation in inflammation and cancer development
An Old Drug's New Trick: Turning Cancer's Survival Signal Into a Death Warrant
Discover how metformin, a common diabetes drug, triggers cancer cell death by activating the ROS-AMPK-ULK1 signaling pathway through AXL mediation in esophageal adenocarcinoma.
RGC-32: The Cellular Double Agent Rewriting Textbooks on Cancer and Disease
Explore RGC-32, the fascinating cellular regulator with dual roles in cancer progression and suppression, and its potential as a therapeutic target.
The Double Agent: How Insulin Commandeers a Cell's Engine to Fuel Cancer
Discover how insulin regulates the glycolytic enzyme PKM2 to enhance cancer cell metabolism and fuel tumor growth through the Warburg Effect.
How Cisplatin Fights Cancer: DNA Damage and Metabolic Starvation
Discover how cisplatin suppresses cancer growth through dual mechanisms - DNA damage and inhibition of integrin β5-mediated glycolysis in breast and cervical cancers.
The Jekyll and Hyde of Cells: How a Tiny Molecular Switch Fuels Cancer
Explore how Akt protein regulation through phosphorylation and acetylation drives cancer progression and treatment resistance
Glycogen: The Trojan Horse of Cancer Cells
Exploring how glycogen metabolism plays a crucial role in the cancer microenvironment and provides new therapeutic targets for cancer treatment.
The Sugar Trap: How Brain Cancer's "Supercells" Thrive on Empty
Discover how Glioblastoma Stem-like Cells use the WNT/β-Catenin pathway to survive glucose deprivation and fuel cancer recurrence.
The Dual-Life of a Cellular Shapeshifter: How Stem Cell Research is Unraveling the HMGA2 Mystery
Explore how induced pluripotent stem cells are revealing the dual nature of HMGA2 as both a stem cell factor and oncoprotein in development and cancer.